James R. Booth
Department of Communication Sciences and Disorders
Professor, Roxelyn and Richard Pepper Department of Communication Sciences and Disorders
Jo Ann G. and Peter F. Dolle Professor in Learning Disabilities
Frances Searle Building
2240 Campus Drive, Room 2-352
Evanston , IL 60208-2952
Graduate Programs: Communication Sciences and Disorders, Interdepartmental Program in Neuroscience, Department of Psychology
The overall goal of our research is to understand mechanisms of brain development. The theoretical framework guiding our research is that development should be associated with age-related increases in the specialization of and the interaction between brain regions. In other words, the brain should segregate into regions with unique computational principles but these regions should also become more integrated. Much of our work focuses on recently invented symbol systems involved in reading and math, so we are investigating how acquisition of these systems is constrained by evolutionarily older brain structures. Our models of typical brain function are also informed by our work in atypical conditions such as dyslexia (reading disability), dyscalculia (math disability) and attention deficit hyperactivity disorder (ADHD). The social and economic costs of illiteracy are enormous, yet we know little about its brain basis, so our work has important implications for the identification and treatment of developmental disorders. Recent work in our lab is investigating the role of educational interventions for changing brain function. We use multimodal neuroimaging to understand the developmental and learning processes including functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI) and event-related potentials (ERPs). Over the years, we have emphasized the use of a priori effective connectivity models to understand the dynamics of brain function, but more recently we are employing large-scale functional connectivity methods to investigate patterns of segregation and integration.
Principal Investigator: Developmental Cognitive Neuroscience Laboratory
|PhD||Psychology, University of Maryland, College Park|
|MS||Psychology, University of Maryland, College Park|
|BA||Psychology, University of Michigan, Ann Arbor|
Liu L, Wang W, You W, Li Y, Awati N, Zhao X, Booth JR & Peng D (2012). Similar alterations in brain function for phonological and semantic processing to visual characters in Chinese dyslexia. Neuropsychologia, 50, 2224-2232.
Bitan T & Booth JR (2012). Offline improvement in learning to read a novel orthography depends on direct letter instruction. Cognitive Science, 36, 896-918.
Prado J, Mutreja R, Zhang H, Mehta R, Desroches AS, Minas J & Booth JR (2011). Distinct representations of subtraction and multiplication in the neural systems for numerosity and language. Human Brain Mapping, 32, 1932-1947.
Cao F, Khalid K, Lee R, Brennan C, Yang Y, Li K, Bolger DJ & Booth JR (2011). Development of brain networks involved in spoken word processing of Mandarin Chinese. Neuroimage, 57, 750-759.
McNorgan C, Alvarez A, Bhullar A, Gayda J & Booth JR (2011). The prediction of reading skill several years later depends on age and brain region: Implication for developmental models of reading. Journal of Neuroscience, 31, 9641-9648.
Liu L, Vira A, Friedman, Minas J, Bolger DJ, Bitan T & Booth JR (2010). Children with reading disability show brain differences in effective connectivity for visual, but not auditory, word comprehension. PLOS One, 5, e13492.
Bitan T, Lifshitz A, Breznitz & Booth JR (2010). Bidirectional connectivity between hemispheres occurs at multiple levels in language processing, but depends on sex. Journal of Neuroscience, 30, 11576-11585.
Desroches AS, Cone NE, Bolger DJ, Bitan T, Burman DD & Booth JR (2010). Children with reading difficulties show differences in brain regions associated with orthographic processing during spoken language processing. Brain Research, 1356, 73-84.
Cao F, Lee R, Yang Y, Xu G, Li K & Booth JR (2010). Cultural constraints on brain development: Evidence from a developmental study of visual word processing in Mandarin Chinese. Cerebral Cortex, 20, 1223-1233.
|4/12-3/14||Neural development of deductive reasoning. National Institute of Child Health and Human Development.|
|08-13||Neural development and disorders of math processing. National Institute of Child Health and Human Development.|
|08-13||Neural development of lexical processing. National Institute of Child Health and Human Development.|
|Brain and Cognition|
|CSD 434||Neuropsychology of Learning Disabilities|
|CSD 551||Developmental Cognitive Neuroscience|